The goal in cleaning the house is killing any live lice or nits that are not on someone’s head when the medicated shampoo (or other treatment) is used. What we recommend.

1. Vacuum your child’s room.
2. Soak combs for 1 hour in container with some water and some anti-lice shampoo or cream rinse.
3. Wash your child’s sheets, blankets, pillowcases, and any clothes worn in the past 3 days in hot water (nits and lice are killed in water at least 140 degrees).
4. Hats, coats, scarves, pillows, fabric couch coverings and other items that cannot be washed should be set aside in sealed plastic bags for 2 weeks. This will ensure that any live lice or nits have died. Note: the over-the-counter “lice control” sprays are probably not worthwhile.

1. Nix® (permethrin) is an over the counter cream rinse that is an effective treatment for lice. It is applied to hair that has been washed with a non-conditioning shampoo then towel dried. The hair and scalp should be saturated with the cream rinse. Leave the Nix on the hair for 10 minutes then rinse out. If live lice are seen in 7-10 days, the treatment with Nix should be repeated.
2. Rid Lice-Killing Shampoo® (pyrethrium and piperonyl butoxide) is an over the counter treatment. Apply thoroughly to dry hair and to the skin areas behind the ears and behind the neck. Leave on the hair for 10 minutes. Then use warm water to make a lather and rinse well. A second treatment needs to be done in 7-10 days to kill any newly hatched lice.
3. LiceMD® (dimethicone) is another over the counter treatment. It is applied to the hair and then you wait for 10 minutes. Then the comb that comes with the package is used to comb out the dead lice and the nits. Afterwards, wash the hair with shampoo and warm water. The treatment can be repeated later if the first treatment was not successful.

1. Sklice® (ivermectin) is a prescription lotion that is highly effective. Sklice® is applied to dry hair. Leave on for 10 minutes then rinse out with water. Avoid contact with eyes and mouth. The Sklice® can be repeated in 10-14 days if live lice are re-seen. Sklice® is approved for use down to 6 months of age.
2. Ovide® (malathion) is a prescription lotion that is used if over-the-counter treatments have not been effective. Ovide® is applied to dry hair. Allow hair to dry naturally. Leave in over night then shampoo out in the morning. A second treatment in one week is usually not needed, but the above treatment should be repeated if live lice are seen in one week. Ovide® is not approved for children less than 2 years of age. There is now a generic available.
3. Natroba® (spinosad) is a prescription topical suspension. It is applied for 10 minutes to the scalp and washed out with warm water. Nit combing is not required as this product kills both live lice and nits. It should be retreated in 7 days if there are live lice still present. As it is a new medication, it is expensive – with out of pocket expense being about $300.
4. Ulesfia® (benzoyl alcohol) is a prescription lotion that smothers the live lice. A large volume is needed to smother the lice, but it can be a highly effective treatment. It is available with a doctor’s prescription. The hair is saturated with the lotion and left on for 10 minutes. The treatment is repeated in one week (7 days) in order to kill any live louse that hatched from an egg (nit) after the first treatment. The out-of-pocket expense would be approximately $50 per bottle (multiple bottles are needed for a treatment) and your insurance is likely to cover a part of the cost.
5. The LouseBuster® is a treatment that uses controlled heated air through a special device. It is chemical free and kills both the lice and the eggs. It is done in your home by the company’s treatment professionals. It is highly effective, but expensive: $99 or more. Any other household members requiring treatment are treated at a discount. Your insurance may reimburse you for part or all of this cost.
6. A course of the oral antibiotic Bactrim®. With resistant cases, Bactrim® can be effective at clearing the lice infection. It is believed to kill the lice by killing bacteria in the louse’s gut. Bactrim® is available as a generic and requires a doctor’s prescription. The complete 10 day course of the antibiotic is required. It is sometimes combined with treating with a medicated hair treatment (such as Nix® or Ovide®).

Smothering (or suffocating) the live lice with the use of Vaseline petroleum jelly, olive oil, butter, or mayonnaise is untested and therefore hard to recommend. Because these treatments are not as likely as Nix or other available treatments to work well, we cannot actively recommend these treatments. These would certainly be difficult to remove from the hair later (requiring lots of shampoo). 

Remove the nits from the hair by combing through with a special nit comb. There are various combs available – sometimes packaged with the treatment shampoos or rinses. The LiceMeister® is one of many metal combs that seem to work well and is available over the counter. The nits can be removed by hand individually also. This is not a quick job. It can take quite some time, especially with children with lots of thick, long hair, to comb through the hair and remove the nits.

Some products like LiceMD® and Rid Lice & Egg Comb-Out Gel® can make it easier to remove the nits. These products are not necessary, but can be helpful if you are frustrated with combing through the hair to remove the nits (eggs).

Once the treatment has been done, your child can return to school. For most children, that means that if your child is treated with a medication in the evening and you have done your best to remove nits from the hair that evening, they can return to school the following day. If your child has live lice, they are still contagious. Many schools still have a “no nits” policy, meaning that they have to be free of nits (the lice eggs) before they can return to school. Since after treatment the nits could be live or dead, it can be difficult to tell whether your child could still have live lice hatch and be contagious. So although we do not feel that it is practical to have a school policy of no nits before return to school, it is best to remove all the nits to the best of your ability. 

As of the summer of 2014, we had seen so much resistance by the lice to the over the counter treatments that we decided to change our recommendations about lice treatment. Please recall that having lice is not an emergency and can be dealt with during routine daytime office hours. We ask you to call at that time if you need to call us concerning lice.

If you find live lice:

1. Call our office during routine office hours to discuss prescription strength medication OR use the over-the-counter Nix® treatment.
2. Clean the house.
3. Remove nits from the hair.
4. Your child is no longer contagious and can return to school the next day.

If you used the Nix® and see live lice in 7-10 days:

1. Repeat the over-the-counter Nix®. These live lice are likely newly-hatched lice from nits and not lice that survived the first treatment.

If you tried Rid® or LiceMD® or another over-the-counter treatment (but not Nix®) and you see live lice within a few days after using the product:

1. Use Nix® instead. Or consider calling during routine office hours to discuss the use of a prescription medication. 
2. Clean the house.
3. Remove any nits that you see.

If you see live lice within the first 4-5 days after using Nix®:

1. Call us during regular business hours to discuss further treatment. We successfully treat many of these children with the prescription strength Sklice®, Ovide®, or Natroba®. The other prescription strength medications (or treatments such as the LouseBuster®) also will likely work, too.
2. Clean the house again.
3. Remove any nits that you find.

If you used a product that killed the lice and you find live lice more than 2 weeks after the treatment:

1. Repeat the treatment. Your child likely became re-infected (from a family member, from school, etc.) and a second treatment will likely be effective.
2. Again clean the house.
3. Remove any nits that you find.

Last Updated: 06/2019

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